Easy File Locker
Easy File Locker is freeware.

Easy File Locker is a light-weight and easy-to-use file lock software product for Windows. It can protect your private files and folders. With its great protection, users will not be able to open, read, modify, delete, move, copy the locked files/folders, or even not be able to see it. The hidden files/folders will be totally invisible to all users and to any program.

Easy File Locker will keep protecting the files/folders even under Windows Safe Mode. It is designed for protecting files/folders on your local computer. it doesn't change the protected files and folders, it will not slow down the system speeds and it will never have the chance to destroy your data.